Hey there! When it comes to Runewords in the Diablo series, they can truly make a difference in your gear setup. Remember that the order of the runes matters, so make sure to place them correctly. Pay attention to the bonuses they provide and try to synergize them with your character’s build. Also, keep in mind the level requirements for each Runeword, as you don’t want to create something you can’t use yet. Lastly, always aim for high-level runes for more powerful effects. Happy crafting!