Hey fellow Nephalem! When it comes to loot in the Diablo series, efficient resource management is key. Make sure to prioritize picking up items that are valuable for crafting or selling, especially rare and legendary items. Enchantments can greatly enhance your gear, so always consider rerolling stats to optimize your build. Crafting can also be a game-changer – focus on crafting gear that complements your playstyle for maximum effectiveness. Remember, the best loot is the one that helps you push further in the Greater Rifts! Happy hunting!