Hey there! When it comes to Runewords in the Diablo series, they can really make a difference in your gear setup. Make sure to pay attention to the order in which you insert the runes into the item, as it affects the outcome. Consider the bonuses each rune provides and how they synergize with your build. Also, keep in mind the level requirement of the item you’re socketing, as it can affect the outcome of the Runeword. Experiment with different combinations to find the ones that complement your playstyle the best. Happy hunting!