Hey there! When it comes to Runewords in the Diablo series, they can truly make a difference in your gear setup. Remember, each Runeword has specific rune requirements, so plan accordingly. Opt for Runewords that complement your build, focusing on enhancing your strengths or compensating for weaknesses. Efficient resource management is key – farm runes strategically and consider trading with other players to complete high-tier Runewords. Don’t forget to keep an eye out for rare runes to create powerful combinations. Happy hunting in Sanctuary!