Hey there fellow Nephalem! When facing bosses in Diablo III, it’s crucial to understand their mechanics. Always have resistance gear and pay attention to their attack patterns. For optimizing gear, focus on critical hit chance/damage, cooldown reduction, and elemental damage bonuses. Utilize Kanai’s Cube for extra buffs. Efficient leveling is key, so run bounties for materials and do Rifts for experience. Don’t forget to adjust your difficulty level for maximum efficiency! Good luck out there in Sanctuary!