Hey fellow Nephalem! When facing bosses in Diablo III, make sure to study their mechanics to know when to dodge or use defensive skills. For gear optimization, focus on critical hit chance, critical hit damage, and elemental damage bonuses that synergize with your skills. Efficient leveling is key, so consider running rifts or bounties in Adventure Mode for experience and loot. Don’t forget to regularly upgrade your artisans and craft or reforge gear to stay ahead of the difficulty curve. Good luck on your demon-slaying journey!