Hey there fellow Nephalem! When it comes to defeating bosses in Diablo III, it’s all about understanding their mechanics. Make sure to dodge telegraphed attacks and focus on dealing burst damage during their vulnerable phases. For optimizing gear, prioritize stats that complement your build such as Critical Hit Chance, Critical Hit Damage, and Cooldown Reduction. Don’t forget to augment your ancient items with legendary gems for that extra boost. When it comes to leveling efficiently, consider running rifts in Adventure Mode or tackling bounties for a good experience yield. Also, don’t underestimate the power of Kanai’s Cube for extracting legendary powers to enhance your build further. Happy hunting in Sanctuary!