Hey fellow Nephalem! When facing Diablo III bosses, focus on building a balanced character with high damage output and survivability. Learn boss mechanics to dodge attacks effectively. For gear optimization, prioritize critical hit chance/damage, cooldown reduction, and elemental damage bonuses. Level efficiently by running Rifts or Bounties on higher difficulties for better XP and loot. Don’t forget to upgrade your artisans to craft powerful gear. Happy hunting in Sanctuary!