Hey there! When it comes to Paragon leveling in Diablo, efficiency is key. Make sure to focus on running high Greater Rifts at a difficulty level that allows you to clear them quickly. Also, joining groups can help you level up faster due to the increased experience bonuses from playing in a party.

In terms of optimizing gear, prioritize getting items with the right stats for your build. Don’t forget to augment your ancient gear with Caldesann’s Despair for an extra boost. And when facing bosses, make sure to understand their mechanics and adjust your skills and playstyle accordingly. Good luck and happy hunting!