Hey fellow Diablo enthusiast! Runes are such an essential aspect of the game, adding a whole new layer of depth to character customization and skill rotations. Each rune can completely change how a skill functions, allowing for a variety of playstyles within each class. It’s crucial to experiment with different rune combinations to maximize your build’s effectiveness. When it comes to dungeon explorations, having the right rune setup can make a significant difference in your survivability and damage output. Remember to constantly tweak your skill rotations based on the runes you equip to adapt to different challenges you may face in the game. Happy hunting in Sanctuary!