Hey fellow Nephalem! When it comes to skills in Diablo, it’s crucial to synergize them for maximum effectiveness. For boss fights, focus on high single-target damage skills like Hammer of the Ancients for Barbarians or Cluster Arrow for Demon Hunters. Make sure to also include defensive skills such as Diamond Skin for Wizards to stay alive during intense battles.

When optimizing gear, tailor your skills to complement your equipment bonuses. For example, if you have items that boost Fire damage, consider using skills like Meteor or Conflagrate. Experiment with different combinations to find what works best for your playstyle.

Lastly, for efficient leveling, prioritize skills that have high area-of-effect damage to clear mobs quickly. Skills like Wave of Light for Monks or Corpse Explosion for Necromancers are great for clearing crowds. Don’t forget to adjust your skills as you level up to keep up with the increasing difficulty. Happy hunting in Sanctuary!